Drug interactions
Mifepristone + Tretinoin
Severity: Moderate
Mifepristone and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral tretinoin is partly metabolized by CYP2C8 and other CYPs, so mifepristone may increase its levels. This could intensify retinoid toxicity such as headache, hypertriglyceridemia and differentiation syndrome.
What this interaction means in plain words
Mifepristone and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tretinoin belongs to Dermatology.
Why it happens
Mifepristone inhibits CYP2C8-mediated tretinoin metabolism, potentially raising exposure.
What to do
Monitor for retinoid toxicity and check lipids and liver tests periodically. Consider tretinoin dose reduction if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Mifepristone with Tretinoin?
MediHelp rates the interaction as moderate. Mifepristone and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral tretinoin is partly metabolized by CYP2C8 and other CYPs, so mifepristone may increase its levels. This could intensify retinoid toxicity such as headache, hypertriglyceridemia and differentiation syndrome.
How serious is the interaction between Mifepristone and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for retinoid toxicity and check lipids and liver tests periodically. Consider tretinoin dose reduction if adverse effects develop.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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