Drug interactions
Mifepristone + Vincristine
Severity: Major
Mifepristone and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is metabolized by CYP3A, and inhibitors can increase exposure, leading to severe neurotoxicity such as neuropathy, constipation or ileus and seizures. Mifepristone is a CYP3A4 inhibitor, so this risk applies.
What this interaction means in plain words
Mifepristone and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Vincristine belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, decreasing vincristine clearance.
What to do
Avoid the combination if possible. If unavoidable, monitor closely for neuropathy and bowel dysfunction and reduce the vincristine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Mifepristone with Vincristine?
MediHelp rates the interaction as major. Mifepristone and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vincristine is metabolized by CYP3A, and inhibitors can increase exposure, leading to severe neurotoxicity such as neuropathy, constipation or ileus and seizures. Mifepristone is a CYP3A4 inhibitor, so this risk applies.
How serious is the interaction between Mifepristone and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, monitor closely for neuropathy and bowel dysfunction and reduce the vincristine dose as needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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