Drug interactions
Mifepristone + Vinorelbine
Severity: Major
Mifepristone and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is extensively metabolized by CYP3A4, so inhibition by mifepristone may raise its levels. This can increase neutropenia, neuropathy and constipation.
What this interaction means in plain words
Mifepristone and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Vinorelbine belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, reducing vinorelbine clearance.
What to do
Avoid if possible; otherwise monitor complete blood counts and neurological symptoms closely and reduce the vinorelbine dose if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Mifepristone with Vinorelbine?
MediHelp rates the interaction as major. Mifepristone and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinorelbine is extensively metabolized by CYP3A4, so inhibition by mifepristone may raise its levels. This can increase neutropenia, neuropathy and constipation.
How serious is the interaction between Mifepristone and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor complete blood counts and neurological symptoms closely and reduce the vinorelbine dose if toxicity develops.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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