Drug interactions
Mifepristone + Zuranolone
Severity: Moderate
Mifepristone and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and is expected to increase zuranolone exposure, raising the risk of excessive sedation, somnolence and impaired driving ability.
What this interaction means in plain words
Mifepristone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Zuranolone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by mifepristone reduces zuranolone metabolism, increasing exposure.
What to do
Reduce the zuranolone dose as recommended for strong CYP3A4 inhibitors and monitor for sedation and CNS depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Mifepristone with Zuranolone?
MediHelp rates the interaction as moderate. Mifepristone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and is expected to increase zuranolone exposure, raising the risk of excessive sedation, somnolence and impaired driving ability.
How serious is the interaction between Mifepristone and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zuranolone dose as recommended for strong CYP3A4 inhibitors and monitor for sedation and CNS depression.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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