Drug interactions
Milnacipran + Selegiline
Severity: Contraindicated
Milnacipran and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and combining it with an SNRI can cause serotonin syndrome and hypertensive reactions. MAOI combinations with milnacipran are contraindicated in labeling.
What this interaction means in plain words
Milnacipran and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Milnacipran belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Inhibition of monoamine breakdown by selegiline together with serotonin and norepinephrine reuptake blockade.
What to do
Do not coadminister. Observe at least 14 days after stopping selegiline before starting milnacipran, and 5 days after stopping milnacipran before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Milnacipran with Selegiline?
MediHelp rates the interaction as contraindicated. Milnacipran and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO inhibitor, and combining it with an SNRI can cause serotonin syndrome and hypertensive reactions. MAOI combinations with milnacipran are contraindicated in labeling.
How serious is the interaction between Milnacipran and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Observe at least 14 days after stopping selegiline before starting milnacipran, and 5 days after stopping milnacipran before starting selegiline.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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