Drug interactions
Mipomersen + Nabumetone
Severity: Moderate
Mipomersen and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver aminotransferases and carries a boxed warning for hepatotoxicity. Nabumetone can occasionally cause liver enzyme elevations, so use together may complicate liver monitoring.
What this interaction means in plain words
Mipomersen and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes according to the mipomersen monitoring schedule and interrupt the drugs if aminotransferases rise significantly. Consider an alternative analgesic in patients with pre-existing liver disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Mipomersen with Nabumetone?
MediHelp rates the interaction as moderate. Mipomersen and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver aminotransferases and carries a boxed warning for hepatotoxicity. Nabumetone can occasionally cause liver enzyme elevations, so use together may complicate liver monitoring.
How serious is the interaction between Mipomersen and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes according to the mipomersen monitoring schedule and interrupt the drugs if aminotransferases rise significantly. Consider an alternative analgesic in patients with pre-existing liver disease.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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