Drug interactions
Mipomersen + Nitrofurantoin
Severity: Moderate
Mipomersen and Nitrofurantoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity and raise transaminases, and nitrofurantoin can also cause liver injury, including hepatitis. Using both may make liver injury harder to detect or more likely.
What this interaction means in plain words
Mipomersen and Nitrofurantoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity through pharmacodynamic effects.
What to do
Check liver tests before starting and monitor them periodically during combined use. Stop nitrofurantoin if transaminases rise unexpectedly or symptoms of hepatitis appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Mipomersen with Nitrofurantoin?
MediHelp rates the interaction as moderate. Mipomersen and Nitrofurantoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause hepatotoxicity and raise transaminases, and nitrofurantoin can also cause liver injury, including hepatitis. Using both may make liver injury harder to detect or more likely.
How serious is the interaction between Mipomersen and Nitrofurantoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver tests before starting and monitor them periodically during combined use. Stop nitrofurantoin if transaminases rise unexpectedly or symptoms of hepatitis appear.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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