Drug interactions
Mipomersen + Simvastatin
Severity: Moderate
Mipomersen and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both simvastatin and mipomersen can raise liver enzymes, and mipomersen carries a hepatotoxicity warning. Using them together may increase the risk of hepatic injury.
What this interaction means in plain words
Mipomersen and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity from two agents that can each elevate transaminases.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during combined therapy. Interrupt therapy if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Mipomersen with Simvastatin?
MediHelp rates the interaction as moderate. Mipomersen and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both simvastatin and mipomersen can raise liver enzymes, and mipomersen carries a hepatotoxicity warning. Using them together may increase the risk of hepatic injury.
How serious is the interaction between Mipomersen and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during combined therapy. Interrupt therapy if significant elevations occur.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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