Drug interactions
Mipomersen + Testosterone
Severity: Moderate
Mipomersen and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mipomersen and testosterone (particularly oral or 17-alpha-alkylated androgens) can raise liver enzymes, so combined use may add to hepatic injury risk. Mipomersen already carries a boxed warning for hepatotoxicity, so additional hepatic stress is relevant.
What this interaction means in plain words
Mipomersen and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential through pharmacodynamic overlap.
What to do
Check liver enzymes and bilirubin before starting and at regular intervals during combined use, per the mipomersen monitoring schedule. Hold or stop the offending drug if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Mipomersen with Testosterone?
MediHelp rates the interaction as moderate. Mipomersen and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mipomersen and testosterone (particularly oral or 17-alpha-alkylated androgens) can raise liver enzymes, so combined use may add to hepatic injury risk. Mipomersen already carries a boxed warning for hepatotoxicity, so additional hepatic stress is relevant.
How serious is the interaction between Mipomersen and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before starting and at regular intervals during combined use, per the mipomersen monitoring schedule. Hold or stop the offending drug if transaminases rise significantly.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Androstenedione, Betamethasone. The full list is on the Testosterone page.
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