Drug interactions
Mirabegron + Nefazodone
Severity: Minor
Mirabegron and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is metabolized mainly by CYP3A4 with a minor CYP2D6 contribution, so the effect of mirabegron on its levels is probably small. Clinical significance is unlikely.
What this interaction means in plain words
Mirabegron and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical CYP2D6 inhibition by mirabegron affecting a minor metabolic pathway of nefazodone.
What to do
No dose change is needed; monitor for increased nefazodone adverse effects such as sedation or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Nefazodone?
MediHelp rates the interaction as minor. Mirabegron and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone is metabolized mainly by CYP3A4 with a minor CYP2D6 contribution, so the effect of mirabegron on its levels is probably small. Clinical significance is unlikely.
How serious is the interaction between Mirabegron and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for increased nefazodone adverse effects such as sedation or dizziness.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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