Drug interactions
Mirabegron + Pindolol
Severity: Minor
Mirabegron and Pindolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol is partly cleared by CYP2D6, so mirabegron may modestly increase its exposure. This could add to bradycardia or hypotension, though the effect is expected to be small because pindolol also has renal elimination.
What this interaction means in plain words
Mirabegron and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mirabegron inhibits CYP2D6, slightly reducing pindolol metabolism.
What to do
Monitor heart rate and blood pressure when starting mirabegron; adjust pindolol only if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Pindolol?
MediHelp rates the interaction as minor. Mirabegron and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pindolol is partly cleared by CYP2D6, so mirabegron may modestly increase its exposure. This could add to bradycardia or hypotension, though the effect is expected to be small because pindolol also has renal elimination.
How serious is the interaction between Mirabegron and Pindolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting mirabegron; adjust pindolol only if bradycardia or hypotension develops.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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