Drug interactions
Mirabegron + Procainamide
Severity: Moderate
Mirabegron and Procainamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide is partly metabolized by CYP2D6 and has a narrow therapeutic index with proarrhythmic potential. Mirabegron may modestly raise procainamide levels, though much of its clearance is renal and by acetylation.
What this interaction means in plain words
Mirabegron and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mirabegron inhibits CYP2D6, possibly reducing procainamide metabolism.
What to do
Monitor ECG (QRS and QT intervals) and procainamide and NAPA concentrations when starting or stopping mirabegron.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Procainamide?
MediHelp rates the interaction as moderate. Mirabegron and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procainamide is partly metabolized by CYP2D6 and has a narrow therapeutic index with proarrhythmic potential. Mirabegron may modestly raise procainamide levels, though much of its clearance is renal and by acetylation.
How serious is the interaction between Mirabegron and Procainamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QRS and QT intervals) and procainamide and NAPA concentrations when starting or stopping mirabegron.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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