Drug interactions
Mirabegron + Protriptyline
Severity: Moderate
Mirabegron and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is metabolized mainly by CYP2D6, and mirabegron inhibition may raise its concentrations. This can increase anticholinergic effects, tachycardia and cardiac conduction effects.
What this interaction means in plain words
Mirabegron and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mirabegron inhibits CYP2D6, reducing protriptyline metabolism.
What to do
Monitor for tricyclic toxicity including tachycardia and anticholinergic effects, and reduce the protriptyline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Protriptyline?
MediHelp rates the interaction as moderate. Mirabegron and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is metabolized mainly by CYP2D6, and mirabegron inhibition may raise its concentrations. This can increase anticholinergic effects, tachycardia and cardiac conduction effects.
How serious is the interaction between Mirabegron and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity including tachycardia and anticholinergic effects, and reduce the protriptyline dose if needed.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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