Drug interactions
Mirabegron + Venlafaxine
Severity: Moderate
Mirabegron and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is converted by CYP2D6 to the active metabolite desvenlafaxine. Mirabegron inhibition can raise venlafaxine levels relative to its metabolite and may increase blood pressure, heart rate and other adverse effects.
What this interaction means in plain words
Mirabegron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Venlafaxine belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, reducing venlafaxine conversion to desvenlafaxine.
What to do
Monitor blood pressure and heart rate, as both drugs can raise blood pressure. Adjust the venlafaxine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mirabegron and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Mirabegron with Venlafaxine?
MediHelp rates the interaction as moderate. Mirabegron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine is converted by CYP2D6 to the active metabolite desvenlafaxine. Mirabegron inhibition can raise venlafaxine levels relative to its metabolite and may increase blood pressure, heart rate and other adverse effects.
How serious is the interaction between Mirabegron and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, as both drugs can raise blood pressure. Adjust the venlafaxine dose if adverse effects occur.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
