Drug interactions
Mitotane + Salmeterol
Severity: Moderate
Mitotane and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer that can lower salmeterol concentrations, potentially reducing bronchodilator efficacy. The inducing effect can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Mitotane and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Mitotane induces CYP3A4, increasing salmeterol metabolism.
What to do
Monitor asthma or COPD control and consider additional or alternative bronchodilator therapy if symptoms worsen. Reassess after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Salmeterol?
MediHelp rates the interaction as moderate. Mitotane and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer that can lower salmeterol concentrations, potentially reducing bronchodilator efficacy. The inducing effect can persist for weeks after mitotane is stopped.
How serious is the interaction between Mitotane and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control and consider additional or alternative bronchodilator therapy if symptoms worsen. Reassess after mitotane discontinuation.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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