Drug interactions
Mitotane + Sorafenib
Severity: Moderate
Mitotane and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer with a long half-life and induction persists after stopping. It may lower sorafenib exposure and reduce antitumor efficacy.
What this interaction means in plain words
Mitotane and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing sorafenib metabolism.
What to do
Monitor for loss of sorafenib efficacy and consider an alternative approach. Be aware that the inducing effect can last weeks after mitotane is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Sorafenib?
MediHelp rates the interaction as moderate. Mitotane and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer with a long half-life and induction persists after stopping. It may lower sorafenib exposure and reduce antitumor efficacy.
How serious is the interaction between Mitotane and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of sorafenib efficacy and consider an alternative approach. Be aware that the inducing effect can last weeks after mitotane is stopped.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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