Drug interactions
Mitotane + Spironolactone
Severity: Moderate
Mitotane and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone has been reported to reduce the effect of mitotane, and mitotane is labeled to be used cautiously with spironolactone. Reduced mitotane activity could compromise treatment of adrenocortical carcinoma.
What this interaction means in plain words
Mitotane and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Spironolactone belongs to Cardiovascular.
Why it happens
Spironolactone may antagonise mitotane's adrenolytic activity; the exact mechanism is not fully established.
What to do
Avoid the combination where possible, using an alternative diuretic. If unavoidable, monitor mitotane plasma levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Spironolactone?
MediHelp rates the interaction as moderate. Mitotane and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Spironolactone has been reported to reduce the effect of mitotane, and mitotane is labeled to be used cautiously with spironolactone. Reduced mitotane activity could compromise treatment of adrenocortical carcinoma.
How serious is the interaction between Mitotane and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using an alternative diuretic. If unavoidable, monitor mitotane plasma levels and clinical response.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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