Drug interactions
Mitotane + Vinorelbine
Severity: Moderate
Mitotane and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may lower vinorelbine concentrations. This could reduce antitumor efficacy.
What this interaction means in plain words
Mitotane and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Induction of CYP3A4 by mitotane increases vinorelbine metabolism.
What to do
Monitor treatment response and consider that higher vinorelbine doses might be needed, with close toxicity monitoring. Enzyme induction can persist for weeks after stopping mitotane.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Vinorelbine?
MediHelp rates the interaction as moderate. Mitotane and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may lower vinorelbine concentrations. This could reduce antitumor efficacy.
How serious is the interaction between Mitotane and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and consider that higher vinorelbine doses might be needed, with close toxicity monitoring. Enzyme induction can persist for weeks after stopping mitotane.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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