Drug interactions
Mobocertinib + Moxifloxacin
Severity: Major
Mobocertinib and Moxifloxacin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for QT prolongation and moxifloxacin adds to the effect. The combination raises the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Mobocertinib and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, reduce the mobocertinib dose and monitor ECG and electrolytes more often.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Mobocertinib with Moxifloxacin?
MediHelp rates the interaction as major. Mobocertinib and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for QT prolongation and moxifloxacin adds to the effect. The combination raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Mobocertinib and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, reduce the mobocertinib dose and monitor ECG and electrolytes more often.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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