Drug interactions
Mobocertinib + Ribociclib
Severity: Major
Mobocertinib and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong QT, and ribociclib inhibits CYP3A4, raising mobocertinib exposure and further increasing QT risk. Torsades de pointes and other arrhythmias are possible.
What this interaction means in plain words
Mobocertinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition by ribociclib increasing mobocertinib levels.
What to do
Avoid the combination. If unavoidable, reduce the mobocertinib dose and monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Mobocertinib with Ribociclib?
MediHelp rates the interaction as major. Mobocertinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong QT, and ribociclib inhibits CYP3A4, raising mobocertinib exposure and further increasing QT risk. Torsades de pointes and other arrhythmias are possible.
How serious is the interaction between Mobocertinib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, reduce the mobocertinib dose and monitor ECG and electrolytes frequently.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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