Drug interactions
Mobocertinib + Tacrolimus
Severity: Major
Mobocertinib and Tacrolimus: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib can induce CYP3A4 and lower tacrolimus exposure, risking rejection. Both drugs also prolong the QT interval, adding arrhythmia risk.
What this interaction means in plain words
Mobocertinib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mobocertinib induction of CYP3A4 increases tacrolimus metabolism, together with additive QT prolongation.
What to do
Avoid if possible. If used, monitor tacrolimus troughs and adjust the dose, and monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Mobocertinib with Tacrolimus?
MediHelp rates the interaction as major. Mobocertinib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib can induce CYP3A4 and lower tacrolimus exposure, risking rejection. Both drugs also prolong the QT interval, adding arrhythmia risk.
How serious is the interaction between Mobocertinib and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, monitor tacrolimus troughs and adjust the dose, and monitor ECG and electrolytes frequently.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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