Drug interactions
Moexipril + Tolazamide
Severity: Moderate
Moexipril and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may increase the blood glucose lowering effect of sulfonylureas such as tolazamide. Hypoglycemia can occur, especially at the start of combined therapy.
What this interaction means in plain words
Moexipril and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake, adding to the insulin secretagogue effect of the sulfonylurea.
What to do
Monitor blood glucose closely when starting or adjusting moexipril and educate the patient on hypoglycemia symptoms. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Moexipril with Tolazamide?
MediHelp rates the interaction as moderate. Moexipril and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may increase the blood glucose lowering effect of sulfonylureas such as tolazamide. Hypoglycemia can occur, especially at the start of combined therapy.
How serious is the interaction between Moexipril and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting moexipril and educate the patient on hypoglycemia symptoms. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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