Drug interactions
Moexipril + Tolbutamide
Severity: Moderate
Moexipril and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose lowering effect of tolbutamide. This can lead to hypoglycemia, particularly early in combined therapy.
What this interaction means in plain words
Moexipril and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity, adding to the insulin secretagogue effect of the sulfonylurea.
What to do
Monitor blood glucose when moexipril is started or the dose changed and teach the patient to recognize hypoglycemia. Lower the tolbutamide dose if glucose falls too low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Moexipril with Tolbutamide?
MediHelp rates the interaction as moderate. Moexipril and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may enhance the glucose lowering effect of tolbutamide. This can lead to hypoglycemia, particularly early in combined therapy.
How serious is the interaction between Moexipril and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when moexipril is started or the dose changed and teach the patient to recognize hypoglycemia. Lower the tolbutamide dose if glucose falls too low.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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