Drug interactions
Moexipril + Tolfenamic acid
Severity: Moderate
Moexipril and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the blood pressure lowering effect of ACE inhibitors like moexipril. In susceptible patients, such as older adults or those who are volume depleted, the combination can also impair renal function and raise potassium.
What this interaction means in plain words
Moexipril and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis opposes ACE inhibitor vasodilation and reduces renal perfusion, with sodium and fluid retention.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Moexipril with Tolfenamic acid?
MediHelp rates the interaction as moderate. Moexipril and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the blood pressure lowering effect of ACE inhibitors like moexipril. In susceptible patients, such as older adults or those who are volume depleted, the combination can also impair renal function and raise potassium.
How serious is the interaction between Moexipril and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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