Drug interactions
Moexipril + Voclosporin
Severity: Moderate
Moexipril and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and nephrotoxicity, and ACE inhibitors add to the potassium-raising and renal hemodynamic effects. The combination may worsen kidney function or raise potassium.
What this interaction means in plain words
Moexipril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor-induced afferent vasoconstriction and reduced potassium excretion combine with ACE inhibitor efferent dilation and reduced aldosterone.
What to do
Monitor eGFR and serum potassium regularly, especially after dose changes. Adjust or reduce voclosporin per labeling if renal function falls or hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Moexipril with Voclosporin?
MediHelp rates the interaction as moderate. Moexipril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and nephrotoxicity, and ACE inhibitors add to the potassium-raising and renal hemodynamic effects. The combination may worsen kidney function or raise potassium.
How serious is the interaction between Moexipril and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum potassium regularly, especially after dose changes. Adjust or reduce voclosporin per labeling if renal function falls or hyperkalemia develops.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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