Drug interactions
Molindone + Promethazine
Severity: Moderate
Molindone and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine receptors and cause sedation, so combined use may increase extrapyramidal symptoms, drowsiness and, rarely, neuroleptic malignant syndrome. Promethazine's anticholinergic effects may also add to those of the antipsychotic.
What this interaction means in plain words
Molindone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 antagonism and CNS depression.
What to do
Monitor for oversedation, extrapyramidal symptoms and signs of neuroleptic malignant syndrome such as fever and rigidity. Use the lowest effective doses and consider a non-dopamine-blocking antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Molindone and Promethazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Molindone with Promethazine?
MediHelp rates the interaction as moderate. Molindone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block dopamine receptors and cause sedation, so combined use may increase extrapyramidal symptoms, drowsiness and, rarely, neuroleptic malignant syndrome. Promethazine's anticholinergic effects may also add to those of the antipsychotic.
How serious is the interaction between Molindone and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, extrapyramidal symptoms and signs of neuroleptic malignant syndrome such as fever and rigidity. Use the lowest effective doses and consider a non-dopamine-blocking antiemetic.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
