Drug interactions
Mometasone inhaled + Ribociclib
Severity: Minor
Mometasone inhaled and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mometasone is cleared by CYP3A4, and strong inhibitors can raise systemic corticosteroid exposure. With inhaled use the systemic exposure is low, but ribociclib may still increase it, with a small risk of cortisol suppression with prolonged use.
What this interaction means in plain words
Mometasone inhaled and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated mometasone metabolism by ribociclib.
What to do
No dose change is usually needed; monitor for signs of systemic corticosteroid excess if used long term at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Mometasone inhaled with Ribociclib?
MediHelp rates the interaction as minor. Mometasone inhaled and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mometasone is cleared by CYP3A4, and strong inhibitors can raise systemic corticosteroid exposure. With inhaled use the systemic exposure is low, but ribociclib may still increase it, with a small risk of cortisol suppression with prolonged use.
How serious is the interaction between Mometasone inhaled and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for signs of systemic corticosteroid excess if used long term at high doses.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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