Drug interactions
Morphine + Naratriptan
Severity: Minor
Morphine and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and opioids have both been associated with serotonin syndrome in labeling, although the evidence for morphine is weak and cases are rare. The risk is greater with other serotonergic drugs.
What this interaction means in plain words
Morphine and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Naratriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic activity; morphine has minimal direct serotonin reuptake effects.
What to do
No routine change is required; counsel patients to report agitation, tremor, sweating, diarrhea or fever promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Morphine with Naratriptan?
MediHelp rates the interaction as minor. Morphine and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triptans and opioids have both been associated with serotonin syndrome in labeling, although the evidence for morphine is weak and cases are rare. The risk is greater with other serotonergic drugs.
How serious is the interaction between Morphine and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required; counsel patients to report agitation, tremor, sweating, diarrhea or fever promptly.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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