Drug interactions
Morphine + Prasugrel
Severity: Moderate
Morphine and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine slows gastric emptying and delays and reduces absorption of oral prasugrel's active metabolite, potentially blunting early platelet inhibition in acute coronary syndrome. This may leave patients at higher short-term thrombotic risk.
What this interaction means in plain words
Morphine and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Opioid-induced delayed gastric emptying reduces and delays absorption of oral prasugrel.
What to do
In acute coronary syndrome, consider a parenteral antiplatelet agent or use non-opioid analgesia where feasible. Avoid relying on oral prasugrel for rapid effect after morphine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Morphine with Prasugrel?
MediHelp rates the interaction as moderate. Morphine and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Morphine slows gastric emptying and delays and reduces absorption of oral prasugrel's active metabolite, potentially blunting early platelet inhibition in acute coronary syndrome. This may leave patients at higher short-term thrombotic risk.
How serious is the interaction between Morphine and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In acute coronary syndrome, consider a parenteral antiplatelet agent or use non-opioid analgesia where feasible. Avoid relying on oral prasugrel for rapid effect after morphine.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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