Drug interactions
Morphine + Procarbazine
Severity: Major
Morphine and Procarbazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity, so opioids may cause excessive CNS depression, hypotension or serotonin toxicity. Morphine labeling advises against use with MAOIs.
What this interaction means in plain words
Morphine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Morphine belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine may potentiate CNS depression and serotonergic or hypotensive effects of the opioid.
What to do
Avoid if possible; if morphine is needed, start at a reduced dose with slow titration and monitor sedation, respiration and blood pressure. Monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Morphine with Procarbazine?
MediHelp rates the interaction as major. Morphine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has MAO-inhibiting activity, so opioids may cause excessive CNS depression, hypotension or serotonin toxicity. Morphine labeling advises against use with MAOIs.
How serious is the interaction between Morphine and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if morphine is needed, start at a reduced dose with slow titration and monitor sedation, respiration and blood pressure. Monitor for serotonin toxicity.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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