Drug interactions
Morphine + Propafenone
Severity: Minor
Morphine and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6, but morphine is cleared mainly through glucuronidation, so a relevant rise in morphine exposure is unlikely. Propafenone can cause dizziness, and some additive CNS effects are possible.
What this interaction means in plain words
Morphine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Propafenone belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition, which is a minor pathway for morphine.
What to do
No dose change is generally needed; monitor analgesic response and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Morphine with Propafenone?
MediHelp rates the interaction as minor. Morphine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone inhibits CYP2D6, but morphine is cleared mainly through glucuronidation, so a relevant rise in morphine exposure is unlikely. Propafenone can cause dizziness, and some additive CNS effects are possible.
How serious is the interaction between Morphine and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor analgesic response and sedation.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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