Drug interactions
Morphine + Quetiapine
Severity: Moderate
Morphine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is strongly sedating and can add to the sedative and respiratory depressant effects of morphine. Orthostatic hypotension and impaired psychomotor performance may also be amplified.
What this interaction means in plain words
Morphine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid receptor agonism and quetiapine's antihistaminic and antiadrenergic activity.
What to do
Start with lower doses of one or both drugs and titrate slowly. Monitor sedation level, blood pressure and breathing, and warn patients about driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Morphine with Quetiapine?
MediHelp rates the interaction as moderate. Morphine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is strongly sedating and can add to the sedative and respiratory depressant effects of morphine. Orthostatic hypotension and impaired psychomotor performance may also be amplified.
How serious is the interaction between Morphine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses of one or both drugs and titrate slowly. Monitor sedation level, blood pressure and breathing, and warn patients about driving or operating machinery.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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