Drug interactions
Morphine + Ramelteon
Severity: Minor
Morphine and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is a mild hypnotic that can add modestly to the drowsiness caused by morphine. The clinical effect is generally small, though some patients, especially older adults, may feel excessively sedated.
What this interaction means in plain words
Morphine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Ramelteon belongs to Central Nervous System.
Why it happens
Possible additive CNS depression through melatonin receptor agonism combined with opioid effects.
What to do
No dose change is usually needed. Advise patients to watch for excess daytime drowsiness and take ramelteon only at bedtime.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Morphine with Ramelteon?
MediHelp rates the interaction as minor. Morphine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is a mild hypnotic that can add modestly to the drowsiness caused by morphine. The clinical effect is generally small, though some patients, especially older adults, may feel excessively sedated.
How serious is the interaction between Morphine and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Advise patients to watch for excess daytime drowsiness and take ramelteon only at bedtime.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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