Drug interactions
Morphine + Sumatriptan
Severity: Minor
Morphine and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to serotonergic effects, so combining them could theoretically cause serotonin syndrome. Clinical reports are rare, and the combination is often used without problems.
What this interaction means in plain words
Morphine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; the contribution of morphine is weak and not well established.
What to do
No routine change is needed. Make patients aware of serotonin syndrome symptoms and reassess therapy if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Morphine with Sumatriptan?
MediHelp rates the interaction as minor. Morphine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been linked to serotonergic effects, so combining them could theoretically cause serotonin syndrome. Clinical reports are rare, and the combination is often used without problems.
How serious is the interaction between Morphine and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Make patients aware of serotonin syndrome symptoms and reassess therapy if they appear.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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