Drug interactions
Morphine + Ziprasidone
Severity: Moderate
Morphine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone can add to the sedation and orthostatic hypotension caused by morphine. Ziprasidone also prolongs the QT interval, which is a separate concern if other risk factors exist.
What this interaction means in plain words
Morphine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-adrenergic blockade.
What to do
Titrate carefully and monitor sedation and blood pressure. Check ECG and electrolytes if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Morphine with Ziprasidone?
MediHelp rates the interaction as moderate. Morphine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone can add to the sedation and orthostatic hypotension caused by morphine. Ziprasidone also prolongs the QT interval, which is a separate concern if other risk factors exist.
How serious is the interaction between Morphine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate carefully and monitor sedation and blood pressure. Check ECG and electrolytes if QT risk factors are present.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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