Drug interactions
Motherwort + Perphenazine
Severity: Minor
Motherwort and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort is a herbal product traditionally used for its mild sedative properties. Together with perphenazine it may add to drowsiness and impaired psychomotor performance. Clinical data are very limited.
What this interaction means in plain words
Motherwort and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects; the herbal constituents are poorly characterized.
What to do
Counsel patients about additive drowsiness and caution when driving or operating machinery. Consider discontinuing motherwort if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Motherwort with Perphenazine?
MediHelp rates the interaction as minor. Motherwort and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort is a herbal product traditionally used for its mild sedative properties. Together with perphenazine it may add to drowsiness and impaired psychomotor performance. Clinical data are very limited.
How serious is the interaction between Motherwort and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution when driving or operating machinery. Consider discontinuing motherwort if excessive sedation occurs.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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