Drug interactions
Motherwort + Promethazine
Severity: Minor
Motherwort and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is a sedating antihistamine, and motherwort is a herbal product traditionally used for its calming effects. Taken together they may deepen drowsiness and impair alertness and psychomotor performance.
What this interaction means in plain words
Motherwort and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects; the sedative activity of motherwort is poorly characterized.
What to do
Advise patients to avoid driving or operating machinery until they know how the combination affects them. Reduce or stop the herbal product if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Motherwort with Promethazine?
MediHelp rates the interaction as minor. Motherwort and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine is a sedating antihistamine, and motherwort is a herbal product traditionally used for its calming effects. Taken together they may deepen drowsiness and impair alertness and psychomotor performance.
How serious is the interaction between Motherwort and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or operating machinery until they know how the combination affects them. Reduce or stop the herbal product if excessive drowsiness occurs.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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