Drug interactions
Moxifloxacin + Octreotide
Severity: Moderate
Moxifloxacin and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and conduction disturbances, and QT prolongation has been reported. With moxifloxacin the risk of QT-related arrhythmia may be increased.
What this interaction means in plain words
Moxifloxacin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Octreotide belongs to Endocrine.
Why it happens
Additive QT effects, with octreotide-induced bradycardia further favoring torsades de pointes.
What to do
Obtain a baseline ECG and monitor heart rate and QTc. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Moxifloxacin with Octreotide?
MediHelp rates the interaction as moderate. Moxifloxacin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and conduction disturbances, and QT prolongation has been reported. With moxifloxacin the risk of QT-related arrhythmia may be increased.
How serious is the interaction between Moxifloxacin and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc. Correct potassium and magnesium abnormalities.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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