Drug interactions
Moxifloxacin + Olanzapine
Severity: Moderate
Moxifloxacin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a small QT effect and moxifloxacin has a clear one, so combined use may modestly raise the risk of arrhythmia. The concern is greater in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Moxifloxacin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization via potassium channel blockade.
What to do
Check the baseline QTc and correct electrolytes. Monitor the ECG if other QT-prolonging drugs or cardiac risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Moxifloxacin with Olanzapine?
MediHelp rates the interaction as moderate. Moxifloxacin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a small QT effect and moxifloxacin has a clear one, so combined use may modestly raise the risk of arrhythmia. The concern is greater in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Moxifloxacin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct electrolytes. Monitor the ECG if other QT-prolonging drugs or cardiac risk factors are present.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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