Drug interactions
Moxifloxacin + Polysaccharide iron
Severity: Moderate
Moxifloxacin and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron preparations given orally can bind moxifloxacin in the gut and reduce how much is absorbed. Lower antibiotic exposure may lead to treatment failure.
What this interaction means in plain words
Moxifloxacin and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Polyvalent iron cations chelate the fluoroquinolone in the gastrointestinal tract, forming poorly absorbed complexes.
What to do
Give oral moxifloxacin at least 4 hours before or 8 hours after the iron product. No separation is needed if either drug is given by a non-oral route.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Polysaccharide iron?
MediHelp rates the interaction as moderate. Moxifloxacin and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron preparations given orally can bind moxifloxacin in the gut and reduce how much is absorbed. Lower antibiotic exposure may lead to treatment failure.
How serious is the interaction between Moxifloxacin and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral moxifloxacin at least 4 hours before or 8 hours after the iron product. No separation is needed if either drug is given by a non-oral route.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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