Drug interactions
Moxifloxacin + Procainamide
Severity: Contraindicated
Moxifloxacin and Procainamide: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide is a class Ia antiarrhythmic that prolongs QT, and moxifloxacin adds to this effect. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Moxifloxacin and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive blockade of cardiac potassium channels leading to QT prolongation.
What to do
Avoid concurrent use and choose an antibacterial without QT effects. If it cannot be avoided, monitor ECG continuously and keep electrolytes normal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Procainamide?
MediHelp rates the interaction as contraindicated. Moxifloxacin and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procainamide is a class Ia antiarrhythmic that prolongs QT, and moxifloxacin adds to this effect. The combination increases the risk of torsades de pointes.
How serious is the interaction between Moxifloxacin and Procainamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an antibacterial without QT effects. If it cannot be avoided, monitor ECG continuously and keep electrolytes normal.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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