Drug interactions
Moxifloxacin + Sodium citrate / citric acid
Severity: Moderate
Moxifloxacin and Sodium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate-containing alkalinizing solutions are often formulated with aluminum or other cations, and could potentially reduce oral moxifloxacin absorption. Lower exposure could reduce antibacterial efficacy.
What this interaction means in plain words
Moxifloxacin and Sodium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduction in absorption through pH change or complexation in the gut; the effect is not well characterized.
What to do
Separate administration by about 2 hours, giving moxifloxacin first. Check the product for polyvalent cations, which require a longer gap.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Sodium citrate / citric acid?
MediHelp rates the interaction as moderate. Moxifloxacin and Sodium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citrate-containing alkalinizing solutions are often formulated with aluminum or other cations, and could potentially reduce oral moxifloxacin absorption. Lower exposure could reduce antibacterial efficacy.
How serious is the interaction between Moxifloxacin and Sodium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by about 2 hours, giving moxifloxacin first. Check the product for polyvalent cations, which require a longer gap.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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