Drug interactions
Moxifloxacin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Moxifloxacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The magnesium in this bowel preparation chelates oral moxifloxacin and reduces its absorption. Antibiotics may also impair colonic bacterial conversion of picosulfate to its active form, which could weaken bowel cleansing.
What this interaction means in plain words
Moxifloxacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium chelation of moxifloxacin in the gut, and antibiotic suppression of colonic flora needed to activate picosulfate.
What to do
Give oral moxifloxacin at least 2 hours before and not less than 6 hours after the bowel preparation. Confirm adequate bowel cleansing if antibiotics were taken beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Moxifloxacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The magnesium in this bowel preparation chelates oral moxifloxacin and reduces its absorption. Antibiotics may also impair colonic bacterial conversion of picosulfate to its active form, which could weaken bowel cleansing.
How serious is the interaction between Moxifloxacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral moxifloxacin at least 2 hours before and not less than 6 hours after the bowel preparation. Confirm adequate bowel cleansing if antibiotics were taken beforehand.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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