Drug interactions
Moxifloxacin + Typhoid vaccine live
Severity: Major
Moxifloxacin and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live typhoid vaccine requires viable Salmonella Typhi to produce immunity. Moxifloxacin is active against Salmonella and may reduce the vaccine's effectiveness.
What this interaction means in plain words
Moxifloxacin and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial action kills or inhibits the live attenuated vaccine strain, reducing the immune response.
What to do
Give the oral live vaccine at least 24 hours after the last antibiotic dose, or use the inactivated injectable typhoid vaccine if timing is not possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Typhoid vaccine live?
MediHelp rates the interaction as major. Moxifloxacin and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live typhoid vaccine requires viable Salmonella Typhi to produce immunity. Moxifloxacin is active against Salmonella and may reduce the vaccine's effectiveness.
How serious is the interaction between Moxifloxacin and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the oral live vaccine at least 24 hours after the last antibiotic dose, or use the inactivated injectable typhoid vaccine if timing is not possible.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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