Drug interactions
Moxifloxacin + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Moxifloxacin and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate. With QT-prolonging moxifloxacin, the risk of arrhythmia may increase, although inhaled systemic exposure is low.
What this interaction means in plain words
Moxifloxacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on QT interval and cardiac excitability from beta-agonism and fluoroquinolone potassium channel blockade.
What to do
Use only when needed and monitor for palpitations and arrhythmia. Check an ECG in patients with cardiac risk factors and correct potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Moxifloxacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate. With QT-prolonging moxifloxacin, the risk of arrhythmia may increase, although inhaled systemic exposure is low.
How serious is the interaction between Moxifloxacin and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when needed and monitor for palpitations and arrhythmia. Check an ECG in patients with cardiac risk factors and correct potassium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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