Drug interactions
Moxifloxacin + Venlafaxine
Severity: Moderate
Moxifloxacin and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine has been associated with QT prolongation, mainly in overdose or with risk factors, and moxifloxacin adds to the effect. The combination may raise the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Moxifloxacin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct hypokalemia and hypomagnesemia. Consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Venlafaxine?
MediHelp rates the interaction as moderate. Moxifloxacin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine has been associated with QT prolongation, mainly in overdose or with risk factors, and moxifloxacin adds to the effect. The combination may raise the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Moxifloxacin and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct hypokalemia and hypomagnesemia. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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