Drug interactions
Moxifloxacin + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Moxifloxacin and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that can affect heart rate and repolarization. With QT-prolonging moxifloxacin, arrhythmia risk may increase, though inhaled systemic exposure is low.
What this interaction means in plain words
Moxifloxacin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on QT interval and cardiac excitability from beta-agonism and fluoroquinolone potassium channel blockade.
What to do
Monitor for palpitations and arrhythmia and obtain an ECG in patients with cardiac risk factors. Correct hypokalemia, which beta-agonists can worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Moxifloxacin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that can affect heart rate and repolarization. With QT-prolonging moxifloxacin, arrhythmia risk may increase, though inhaled systemic exposure is low.
How serious is the interaction between Moxifloxacin and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia and obtain an ECG in patients with cardiac risk factors. Correct hypokalemia, which beta-agonists can worsen.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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