Drug interactions
Moxonidine + Perphenazine
Severity: Moderate
Moxonidine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness and hypotension, and perphenazine is sedating and has alpha-blocking activity. Used together they may increase sedation and the risk of low blood pressure or dizziness.
What this interaction means in plain words
Moxonidine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central sedation and hypotensive effects from imidazoline receptor agonism and alpha-adrenergic blockade.
What to do
Monitor blood pressure and sedation, especially when starting or increasing either drug. Counsel patients to rise slowly and avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Moxonidine with Perphenazine?
MediHelp rates the interaction as moderate. Moxonidine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness and hypotension, and perphenazine is sedating and has alpha-blocking activity. Used together they may increase sedation and the risk of low blood pressure or dizziness.
How serious is the interaction between Moxonidine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, especially when starting or increasing either drug. Counsel patients to rise slowly and avoid driving if drowsy.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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