Drug interactions
Moxonidine + Tizanidine
Severity: Moderate
Moxonidine and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on central alpha-2 or imidazoline receptors to reduce sympathetic outflow. Together they may cause additive hypotension, bradycardia and drowsiness.
What this interaction means in plain words
Moxonidine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central sympatholytic effects through alpha-2 and imidazoline receptor agonism.
What to do
Monitor blood pressure, heart rate and sedation and titrate slowly. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Moxonidine with Tizanidine?
MediHelp rates the interaction as moderate. Moxonidine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on central alpha-2 or imidazoline receptors to reduce sympathetic outflow. Together they may cause additive hypotension, bradycardia and drowsiness.
How serious is the interaction between Moxonidine and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation and titrate slowly. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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