Drug interactions
Muromonab cd3 + Mycophenolate mofetil
Severity: Major
Muromonab cd3 and Mycophenolate mofetil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 depletes T cells, and combined with mycophenolate it increases the overall degree of immunosuppression. This raises the risk of serious infection and lymphoproliferative disease, though the combination was historically used in transplant protocols.
What this interaction means in plain words
Muromonab cd3 and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion and inhibition of lymphocyte proliferation.
What to do
Use only under transplant specialist protocols with infection prophylaxis and monitoring. Muromonab-CD3 is no longer widely available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Muromonab cd3 with Mycophenolate mofetil?
MediHelp rates the interaction as major. Muromonab cd3 and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Muromonab-CD3 depletes T cells, and combined with mycophenolate it increases the overall degree of immunosuppression. This raises the risk of serious infection and lymphoproliferative disease, though the combination was historically used in transplant protocols.
How serious is the interaction between Muromonab cd3 and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only under transplant specialist protocols with infection prophylaxis and monitoring. Muromonab-CD3 is no longer widely available.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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